Piaru SP, Mahmud R, Abdul Majid AM, Mahmoud Nassar ZD
Asian Pacific Journal of Tropical Medicine, 2012
ABSTRACT:
OBJECTIVE:
To investigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils.
METHODS:
The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.
RESULTS:
The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC50 of 109.30 μg/mL.
CONCLUSIONS:
Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.
CITATION:
Piaru SP, Mahmud R, Abdul Majid AM, Et Al. Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Asian Pac J Trop Med. 2012;5(4):294-298.
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