Investigations into the specific effects of rosemary oil at the receptor level

Sagorchev P, Lukanov J, Beer AM
Phytomedicine, 2010

ABSTRACT:

Rosemary oil is used frequently in phytotherapy. The objective of the present study was to investigate the extent to which rosemary oil shows other effects on the smooth muscles than the familiar spasmolytic effects. The effects of rosemary oil on the spontaneous contractile activity were investigated in in vitro experiments with circular smooth-muscle strips of the guinea pig stomach. Rosemary oil was found to have agonistic effects on the α1 and α2 adrenergic receptors. These effects can be registered at concentrations up to 25μl/l of rosemary oil. At higher concentrations the spasmolytic effect described in other reports could be detected. At concentrations above 100μl/l rosemary oil, the effect of 10−5M ACH is completely suppressed. The results permit the assumption that, besides the spasmolytic effects investigated to date, owing to its specific effects on the α2 adrenergic receptors of the nerve cells, rosemary oil brings about an additional improvement of local blood circulation and alleviates pain.

CITATION:

Sagorchev P, Lukanov J, Beer AM. Investigations into the specific effects of rosemary oil at the receptor level. Phytomedicine. 2010;17(8-9):693-697.

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