Reis Simas DL, Mérida-Reyes MS, Muñoz-Wug MA, Cordeiro MS, Giorno TBS, Taracena EA, Oliva-Hernández BE, Martínez-Arévalo JV, Fernandes PD, Pérez-Sabino JF, Jorge Ribeiro da Silva A
Natural Product Research, 2017
ABSTRACT:
The composition and the antinociceptive activity of the essential oil of Stevia serrata Cav. from a population located in the west highlands of Guatemala were evaluated. A yield of 0.2% (w/w) of essential oil was obtained by hydrodistillation of the dried aerial parts of the plant. The essential oilanalysed by GC-FID and GC-MS showed a high content of sesquiterpenoids, with chamazulene (60.1%) as the major component and 91.5% of the essential oil composition was identified. To evaluate antinociceptive activity in mice, the essential oil of S. serrata Cav. was administered as gavage, using three different doses. In the formalin test, the animals were pre-treated with oral doses of the essential oil before the administration of formalin. Oral administration of S. serrata Cav. essential oil produced a marked antinociceptive activity. Therefore, the plant could be domesticated as a source of essential oilrich in chamazulene for developing medicinal products.
CITATION:
Reis Simas DL, Mérida-Reyes MS, Muñoz-Wug MA et al. Chemical composition and evaluation of antinociceptive activity of the essential oil of Stevia serrata Cav. from Guatemala. Nat Prod Res. 2017 Nov 13:1-3. doi: 10.1080/14786419.2017.1399376.
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