Bouzenna H, Hfaiedh N, Giroux-Metges MA, Elfeki A, Talarmin H Biomedicine & Pharmacotherapy, 2017 ABSTRACT: Alpha-pinene is a key compound of the essential oils extracted from many species of coniferous trees. It is known for its biological activities. The aim of the present study was to determine the preventive effect of alpha-pinene on aspirin-induced toxicity in vitro, using IEC-6 cells, and… Read more »
Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model
Ding Y, Gu Z, Wang Y, Wang S, Chen H, Zhang H, Chen W, Chen YQ Food & Function, 2017 ABSTRACT: Numerous medicinal plants have been reported to prevent various chronic diseases. In this study, we screened a new FASN inhibitor-alcohol extract of clove (AEC) using a fast microplate method developed in our laboratory. The major components of AEC were: eugenol (42.27%), acetyl eugenol (29.12%), caryophyllene (15.40%), and… Read more »
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice
Segat GC, Manjavachi MN, Matias DO, Passos GF, Freitas CS, Costa R, Calixto JB Neuropharmacology, 2017 ABSTRACT: Painful peripheral neuropathy is a common side effect of paclitaxel (PTX). The use of analgesics is an important component for management of PTX-induced peripheral neuropathy (PINP). However, currently employed analgesics have several side effects and are poorly effective. β-caryophyllene (BCP), a dietary selective CB2 agonist, has… Read more »
Beneficial effects of TQRF and TQ nano- and conventional emulsions on memory deficit, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble Aβ levels in high fat-cholesterol diet-induced rats
Ismail N, Ismail M, Azmi NH, Bakar MFA, Yida Z, Stanslas J, Sani D, Basri H, Abdullah MA Chemico-Biological Interactions, 2017 ABSTRACT: The study determined the effect of thymoquinone rich fraction (TQRF) and thymoquinone (TQ) in the forms of nano- and conventional emulsions on learning and memory, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble β-amyloid (Aβ) levels in rats fed… Read more »
Eucalyptol, sabinene and cinnamaldehyde: potent inhibitors of salmonella target protein L-asparaginase
Vimal A, Pal D, Tripathi T, Kumar A 3 Biotech, 2017 ABSTRACT: Salmonella typhimurium is a severe threat to human life. The treatment became more difficult with the emergence of multidrug resistance. In the present in silico study, a novel drug target L-asparaginase was tested against three ligands eucalyptol, sabinene, and cinnamaldehyde, major components of cardamom, nutmeg, and cinnamon, respectively…. Read more »
Antioxidant and antibacterial activities of Pelargonium asperum and Ormenis mixta essential oils and their synergistic antibacterial effect
Ouedrhiri W, Balouiri M, Bouhdid S, Harki EH, Moja S, Greche Environmental Science and Pollution Research International, 2017 ABSTRACT: In this work, the chemical composition, the antioxidant, and the antibacterial activities of two Moroccan essential oils less studied, extracted from Pelargonium asperum and Ormenis mixta, were investigated. According to the gas chromatography coupled to mass spectrometry analysis, citronellol (25.07%), citronellyl… Read more »
(+)-Dehydrofukinone modulates membrane potential and delays seizure onset by GABAa receptor-mediated mechanism in mice
Garlet QI, da Costa Pires L, Milanesi LH, Marafiga JR, Baldisserotto B, de Mello CF, Heinzmann BM Toxicology and Applied Pharmacology, 2017 ABSTRACT: (+)-Dehydrofukinone (DHF), isolated from Nectandra grandiflora (Lauraceae) essential oil, induces sedation and anesthesia by modulation of GABAa receptors. However, no study has addressed whether DHF modulates other cellular events involved in the control of cellular excitability, such as seizure… Read more »
Chemical Composition and Antimigraine Activity of Essential Oil of Angelicae dahuricae Radix
Sun J, Li H, Sun J, Liu H, Chen J, Wang C Journal of Medicinal Food, 2017 ABSTRACT: The aim of this study was to explore the chemical composition and the effect of essential oil of Angelicae dahuricae radix on a nitroglycerin (NTG)-induced rat model of migraine. The CO2 supercritical fluid extraction method was optimized for the extraction of essential oil of A. dahuricae radix… Read more »
Characterization of Essential Oil Composition in Different Basil Species and Pot Cultures by a GC-MS Method
Muráriková A, Ťažký A, Neugebauerová J, Planková A, Jampílek J, Mučaji P, Mikuš P Molecules, 2017 ABSTRACT: Basil (Ocimum L.) species are used as medicinal plants due to their essential oils exhibiting specific biological activity. The present work demonstrated that both the variety and season/conditions of cultivation had a significant effect on (i) the produced amount (extraction yield), (ii) qualitative, as well… Read more »
Evidence for the involvement of the GABAergic, but not serotonergic transmission in the anxiolytic-like effect of bisabolol in the mouse elevated plus maze
Tabari MA, Tehrani MAB Naunyn-Schmiedeberg’s Archives of Pharmacology, 2017 ABSTRACT: Bisabolol (α-(-)-bisabolol) is a sesquiterpene which is a part of the essential oil of a variety of plants, but its common source is German chamomile. Several bioactivities including anti-inflammatory, anti-nociceptive, and anti-tumor effects were attributed to bisabolol. However, the neuropharmacological properties of bisabolol have not yet been reported…. Read more »