Katiki LM, Barbieri AME, Araujo RC, Veríssimo CJ, Louvandini H, Ferreira JFS Veterinary Parasitology, 2017 ABSTRACT: Anthelmintic resistance in sheep gastrointestinal nematodes is a worldwide problem. Multi-drug resistant haemonchosis is the most serious impediment for small ruminant systems, and there are no new drug candidates currently under development. Molecules from natural sources have demonstrated anthelmintic… Read more »
Digestive System
This system includes the mouth, teeth, tongue, esophagus, stomach, small intestine, pancreas, gallbladder, liver, large intestine, rectum and anus. Common disorders include GERD (acid reflux), indigestion, gut motility disorders, ulcerative colitis, Crohn’s disease and peptic or duodenal ulcers.
Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats
Ozkaya A, Sahin Z, Kuzu M, Saglam YS, Ozkaraca M, Uckun M, Yologlu E, Comakli V, Demirdag R, Yologlu S Archives of Physiology and Biochemistry, 2017 ABSTRACT: In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated…. Read more »
α-Bisabolol improves 5-aminolevulinic acid retention in buccal tissues: Potential application in the photodynamic therapy of oral cancer
Quintanilha NP, Dos Santos Miranda Costa I, Freiman de Souza Ramos M, Campos de Oliveira Miguel N, Riemma Pierre MB Journal of Photochemistry and Photobiology, 2017 CONTEXT: 5-Aminolevulinic acid (5-ALA) is a prodrug used in photodynamic therapy (PDT) of tumors, including cancer of the oral mucosa. 5-ALA poorly penetrates oral tissues due to its high… Read more »
Oral administration of thymoquinone mitigates the effect of cisplatin on brush border membrane enzymes, energy metabolism and antioxidant system in rat intestine
Shahid F, Farooqui Z, Abidi S, Parwez I, Khan F Biomedicine & Pharmacotherapy, 2017 ABSTRACT: Cisplatin (CP) is a widely used chemotherapeutic agent that elicits severe gastrointestinal toxicity. Nigella sativa, a member of family Ranunculaceae, is one of the most revered medicinal plant known for its numerous health benefits. Thymoquinone (TQ), a major bioactive component derived from… Read more »
Combination treatment of citral potentiates the efficacy of hyperthermic intraperitoneal chemoperfusion with pirarubicin for colorectal cancer
Fang Z, Wang Y, Li H, Yu S, Liu Z, Fan Z, Chen X, Wu Y, Pan X, Li X, Wang C Molecular Pharmacology, 2017 ABSTRACT: Citral is a widely used penetration enhancer that has been used to assist the delivery of drugs through the skin. In this study we aimed to investigate the effectiveness of… Read more »
Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP-PKA pathway
Tong T, Ryu SE, Min Y, de March CA, Bushdid C, Golebiowski J, Moon C, Park T Scientific Reports, 2017 ABSTRACT: Ectopic expression and functions of odorant receptors (ORs) in the human body have aroused much interest in the past decade. Mouse olfactory receptor 23 (MOR23, olfr16) and its human orthologue, OR10J5, have been found… Read more »
Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol
do Nascimento KF, Moreira FMF, Alencar Santos J, Kassuya CAL, Croda JHR, Cardoso CAL, Vieira MDC, Góis Ruiz ALT, Ann Foglio M, de Carvalho JE, Formagio ASN Journal of Ethnopharmacology, 2017 ETHNOPHARMACOLOGICAL RELEVANCE: Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence… Read more »
Effectiveness of Myrtus communis in the treatment of hemorrhoids
Mahboubi M Journal of Integrative Medicine, 2017 ABSTRACT: Myrtus communis is an important plant in the treatment of many different diseases. The aim of this review was to determine the importance of M. communis essential oil in the treatment of hemorrhoids. For preparing this manuscript, the information was extracted from different resources. The results of… Read more »
GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.
Ayaz M, Junaid M, Ullah F, Sadiq A, Shahid M, Ahmad W, Ullah I, Ahmad A, Syed NI Frontiers in Chemistry, 2017 ABSTRACT: Peptic ulceration is among the most prevalent gastrointestinal disorders characterized by pepsin and gastric acid mediated mucosal damage, as result of imbalance between defensive and offensive processes. The main objective of the… Read more »
Cinnamicaldehyde regulates the expression of tight junction proteins and amino acid transporters in intestinal porcine epithelial cells
Sun K, Lei Y, Wang R, Wu Z, Wu G Journal of Animal Science and Biotechnology, 2017 BACKGROUND: Cinnamicaldehyde (CA) is a key flavor compound in cinnamon essential oil possessing various bioactivities. Tight junction (TJ) proteins are vital for the maintenance of intestinal epithelial barrier function, transport, absorption and utilization of dietary amino acids and other nutrients. In… Read more »