Lee JH, Jeong JK, Park SY International Journal of Endocrinology, 2018 ABSTRACT: BACKGROUND AND PURPOSE: Hinokitiol, a natural monopenoid present in the essential oil of Calocedrus formosana heartwood, exerts potent anticancer, anti-inflammatory, antibacterial, and neuroprotective effects on various cells. However, the antiobesity effect of hinokitiol on adipocytes is unclear. EXPERIMENTAL APPROACH: In this study, we… Read more »
Hinokitiol
- Backbone: Monoterpene
- Functional Group: Tropolone
Antimicrobial Activity of some Pacific Northwest Woods against Anaerobic Bacteria and Yeast
Johnston WH, Karchesy JJ, Constantine GH, Craig AM
Phytotherapy Research:PTR, 2001
Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site
Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E
Structure, 2009
β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity
Hu Y, Cheng X, Cao F, Huang A, Tavis JE
Antiviral Research, 2013
Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase.
Borowski P, Lang M, Haag A, Baier A
Antiviral Chemistry & Chemotherapy, 2007
Structure of HIV-1 Reverse Transcriptase with the Inhibitor b-Thujaplicinol Bound at the RNase H Active Site
Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E
Structure (London, England:1993), 2009
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.
Budihas SR, Gorshkova I, Gaidamakov S, Wamiru A, Bona MK, Parniak MA, Crouch RJ, McMahon JB, Beutler JA, Le Grice SF
Nucleic Acids Research, 2005
Preventive Effects of β-Thujaplicin Against UVB-Induced MMP-1 and MMP-3 mRNA Expressions in Skin Fibroblasts
Cherng JY, Chen LY, Shih MF
The American Journal of Chinese Medicine, 2012
p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function
Liu S, Yamauchi H
Cancer Letters, 2009
Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats.
Imai N, Doi Y, Nabae K, Tamano S, Hagiwara A, Kawabe M, Ichihara T, Ogawa K, Shirai T
The Journal of Toxicological Sciences, 2006