López V, Nielsen B, Solas M, Ramírez MJ, Jäger AK Frontiers in Pharmacology, 2017 ABSTRACT: Lavender essential oil is traditionally used and approved by the European Medicines Agency (EMA) as herbal medicine to relieve stress and anxiety. Some animal and clinical studies reveal positive results in models of anxiety and depression although very little research has… Read more »
Quantitative and qualitative evaluation of a multivitamin mineral herbal essential-oil-infused supplement: a pilot clinical trial
Han X, Parker TL Journal of Dietary Supplements, 2017 ABSTRACT: A complete multivitamin mineral herbal omega 3 supplement infused with essential oils (product name Lifelong Vitality, LLV) has been reported by its users to increase energy levels, decrease pain, strengthen immunity and improve mental focus. This study was designed to quantitatively evaluate these effects through… Read more »
Chemical composition analysis and in vitro biological activities of ten essential oils in human skin cells
Han X, Beaumont C, Stevens N, Parker TL Biochimie Open, 2017 ABSTRACT: Research on the biological effects of essential oils on human skin cells is scarce. In the current study, we primarily explored the biological activities of 10 essential oils (nine single and one blend) in a pre-inflamed human dermal fibroblast system that simulated chronic… Read more »
An essential oil blend significantly modulates immune responses and the cell cycle in human cell cultures
Han X, Dorsett J, Parker TL Cogent Biology, 2017 ABSTRACT: In the current study, we examined the biological activities of an essential oil blend (EOB) in validated human cell cultures, which model the molecular biology of autoimmune diseases and chronic inflammation. EOB is primarily composed of essential oils from wild orange, clove, cinnamon, eucalyptus, and… Read more »
Essential oils diversely modulate genome-wide gene expression in human dermal fibroblasts
Han X, Parker TL Cogent Medicine, 2017 ABSTRACT: The increasing popularity of essential oils for skincare has led to investigation of their biological effects in human skin cells. In this study, we investigated the biological activities of three commercially available essential oils, i.e. rosemary oil, wild orange oil, and a blend (commercial name: Deep Blue)… Read more »
An essential oil blend modulates important inflammation- and immune response-related biomarkers in human cell cocultures
Han X, Price R, Parker TL Cogent Medicine, 2017 ABSTRACT: Despite growing scientific evidence that essential oils possess important therapeutic benefits, research on their biological activities in complex human disease models is scarce. To enhance understanding in this regard, we analyzed the biological activities of an essential oil blend (EOB) in validated human cocultures with… Read more »
Biological activity of vetiver (Vetiveria zizanioides) essential oil in human dermal fibroblasts
Han X, Parker TL Cogent Medicine, 2017 ABSTRACT: Vetiver (Vetiveria zizanioides) essential oil (VEO) has a long history of use. However, research on its biological activity in human skin cells is scarce. In this study, we investigated the biological activity of VEO in a pre-inflamed human dermal fibroblast model, which was designed to mimic the… Read more »
Anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of oregano (Origanum vulgare) essential oil in a human skin disease model
Han X, Parker TL Biochimie Open, 2017 ABSTRACT: The use of oregano (Origanum vulgare) essential oil (OEO) has become popular in skin care products. However, scientific research regarding its effects on human skin cells is scarce. In this study, we investigated the biological activity of a commercially available OEO, which is high in carvacrol content,… Read more »
Melaleuca (Melaleuca alternifolia) essential oil demonstrates tissue-remodeling and metabolism-modulating activities in human skin cells
Han X, Parker TL Cogent Biology, 2017 ABSTRACT: Melaleuca (Melaleuca alternifolia) essential oil (MEO), commonly known as tea tree oil, is popularly used in skincare products. In the current study, we investigated the biological activity of a commercially available MEO (with terpinen-4-ol as the major active component) in pre-inflamed human dermal fibroblasts, which were designed… Read more »
Lemongrass (Cymbopogon flexuosus) essential oil demonstrated anti-inflammatory effect in pre-inflamed human dermal fibroblasts
Han X, Parker TL Biochimie Open, 2017 ABSTRACT: Lemongrass (Cymbopogon flexuosus) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of… Read more »