Katiki LM, Barbieri AME, Araujo RC, Veríssimo CJ, Louvandini H, Ferreira JFS Veterinary Parasitology, 2017 ABSTRACT: Anthelmintic resistance in sheep gastrointestinal nematodes is a worldwide problem. Multi-drug resistant haemonchosis is the most serious impediment for small ruminant systems, and there are no new drug candidates currently under development. Molecules from natural sources have demonstrated anthelmintic… Read more »
Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats
Ozkaya A, Sahin Z, Kuzu M, Saglam YS, Ozkaraca M, Uckun M, Yologlu E, Comakli V, Demirdag R, Yologlu S Archives of Physiology and Biochemistry, 2017 ABSTRACT: In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated…. Read more »
α-Bisabolol improves 5-aminolevulinic acid retention in buccal tissues: Potential application in the photodynamic therapy of oral cancer
Quintanilha NP, Dos Santos Miranda Costa I, Freiman de Souza Ramos M, Campos de Oliveira Miguel N, Riemma Pierre MB Journal of Photochemistry and Photobiology, 2017 CONTEXT: 5-Aminolevulinic acid (5-ALA) is a prodrug used in photodynamic therapy (PDT) of tumors, including cancer of the oral mucosa. 5-ALA poorly penetrates oral tissues due to its high… Read more »
Trans-caryophyllene inhibits amyloid β (Aβ) oligomer-induced neuroinflammation in BV-2 microglial cells
Hu Y, Zeng Z, Wang B, Guo S International Immunopharmacology, 2017 ABSTRACT: Amyloid β (Aβ) is the major component of senile plaques (SP) in the brains of Alzheimer’s disease (AD) patients, and serves as an inflammatory stimulus for microglia. Trans-caryophyllene (TC), a major component in the essential oils derived from various species of medicinal plants, has displayed… Read more »
Oral administration of thymoquinone mitigates the effect of cisplatin on brush border membrane enzymes, energy metabolism and antioxidant system in rat intestine
Shahid F, Farooqui Z, Abidi S, Parwez I, Khan F Biomedicine & Pharmacotherapy, 2017 ABSTRACT: Cisplatin (CP) is a widely used chemotherapeutic agent that elicits severe gastrointestinal toxicity. Nigella sativa, a member of family Ranunculaceae, is one of the most revered medicinal plant known for its numerous health benefits. Thymoquinone (TQ), a major bioactive component derived from… Read more »
(-)-Linalool influence on the cerebral blood flow in healthy male volunteers revealed by three-dimensional pseudo-continuous arterial spin labeling
Ota M, Sato N, Sone D, Ogura J, Kunugi H Indian Journal of Psychiatry, 2017 BACKGROUND: Although aromatherapy is widely used, the pharmacology of the essential oils remains undiscovered. AIM: The present study assessed the effect of (-)-linalool, the main contained material of lavender, on the brain function. MATERIALS AND METHODS: Healthy male volunteers calculated… Read more »
Topical Menthol for Treatment of Chemotherapy-induced Peripheral Neuropathy
Cortellini A, Verna L, Cannita K, Napoleoni L, Parisi A, Ficorella C, Porzio G Indian Journal of Palliative Care, 2017 ABSTRACT: Chemotherapy-induced peripheral neuropathy is a frequent treatment-limiting factor that significantly impairs patients’ everyday life, also because of a lack of valid palliative options. Here, we report a case of a male patient with a history of metastatic… Read more »
Carvacrol promotes angiogenic paracrine potential and endothelial differentiation of human mesenchymal stem cells at low concentrations
Matluobi D, Araghi A, Maragheh BFA, Rezabakhsh A, Soltani S, Khaksar M, Siavashi V, Feyzi A, Bagheri HS, Rahbarghazi R, Montazersaheb S Microvascular Research, 2017 OBJECTIVES: Phenolic monoterpene compound, named Carvacrol, has been found to exert different biological outcomes. It has been accepted that the angiogenic activity of human mesenchymal stem cells was crucial in the… Read more »
Combination treatment of citral potentiates the efficacy of hyperthermic intraperitoneal chemoperfusion with pirarubicin for colorectal cancer
Fang Z, Wang Y, Li H, Yu S, Liu Z, Fan Z, Chen X, Wu Y, Pan X, Li X, Wang C Molecular Pharmacology, 2017 ABSTRACT: Citral is a widely used penetration enhancer that has been used to assist the delivery of drugs through the skin. In this study we aimed to investigate the effectiveness of… Read more »
Critical synergistic concentration of lecithin phospholipids improve the antimicrobial activity of eugenol against Escherichia coli
Zhang H, Dudley EG, Harte F Applied Environmental Microbiology, 2017 ABSTRACT: In this study, the effect of individual lecithin phospholipids on the antimicrobial properties of eugenol against E. coli C600 was investigated. We tested five major phospholipids common in soy or egg lecithin (DPPC, DSPC, DPPE, DPPA and DPPS) and one synthetic cationic phospholipid (EPC 18:0). Among six phospholipids,… Read more »