Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships

Vasconcelos CML, Oliveira ISN, Santos JNA, Souza AA, Menezes-Filho JER, Silva Neto JA, Lima TC, de Sousa DP Natural Product Research, 2017 ABSTRACT: The aim of this work was to evaluate the pharmacological effect of seven structurally related terpenes on the contractility of cardiac muscle. The effect of terpenes was studied on isolated electrically driven guinea pig left atrium. From concentration-response curves… Read more »

The Effect of Aromatherapy on Insomnia and Other Common Symptoms Among Patients With Acute Leukemia

Blackburn L, Achor S, Allen B, Bauchmire N, Dunnington D, Klisovic RB, Naber SJ, Roblee K, Samczak A, Tomlinson-Pinkham K, Chipps E Oncology Nursing Forum, 2017 ABSTRACT: PURPOSE/OBJECTIVES: To determine if the use of aromatherapy improves insomnia and other common symptoms in hospitalized patients with newly diagnosed acute leukemia. DESIGN: A randomized, crossover, washout trial. SETTING: An inpatient acute leukemia unit at the Arthur G…. Read more »

Studies on the Behavior of Eucalyptol and Terpinen-4-ol – Natural Food Additives and Ecological Pesticides – in Model Lipid Membranes

Hąc-Wydro K, Flasiński M, Broniatowski M, Sołtys M Langmuir, 2017 ABSTRACT: Effective application of the essential oils requires detailed exploration of their mechanism of action and the origin of diverse activity of their components. In this work, the influence of eucalyptol and terpinen-4-ol on artificial membranes was studied to verify whether the differences in the activity of these compounds are… Read more »

β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway

Cheng Y, Dong Z, Liu S Pharmacology, 2014 ABSTRACT: BACKGROUND/AIMS: The activation of cannabinoid receptor 2 (CB2) has the beneficial effect of reducing neuroinflammatory response in the treatment of Alzheimer’s disease (AD) and is suggested to trigger the peroxisome proliferator-activated receptor-γ (PPARγ) pathway; agonists of both receptors improve AD. Recently, the plant metabolite β-caryophyllene was… Read more »

The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines

Ambrož M, Matoušková P, Skarka A, Zajdlová M, Žáková K, Skálová L Molecules, 2017 ABSTRACT: β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (NER) and valencene (VAL) are constituents of the essential oil of Myrica rubra (MEO), which has significant antiproliferative effect in various cancer cell lines. In the present study, we compared the antiproliferative effect of… Read more »

Global transcriptional response of Escherichia coli MG1655 cells exposed to the oxygenated monoterpenes citral and carvacrol

Chueca B, Pérez-Sáez E, Pagán R, García-Gonzalo D International Journal of Food Microbiology, 2017 ABSTRACT: DNA microarrays were used to study the mechanism of bacterial inactivation by carvacrol and citral. After 10-min treatments of Escherichia coli MG1655 cells with 100 and 50ppm of carvacrol and citral, 76 and 156 genes demonstrated significant transcriptional differences (p≤0.05),… Read more »

Effect of essential oil mouthwashes on plaque and gingivitis

Richards D Journal of Evidence-Based Dental Practice, 2017 ABSTRACT: Data sources: Medline, Embase, LILACS and Scopus database. Study selection: Studies were screened independently by three reviewers. Randomised controlled trials with a minimum of six months follow-up of daily use of essential oils-containing (EO) mouthwashes compared with placebo, flossing or cetylpyridinium chloride (CPC) as adjuncts to… Read more »

The repellent efficacy of eleven essential oils against adult Dermacentor reticulatus ticks

Štefanidesová K, Škultéty Ľ, Sparagano OAE, Špitalská E Ticks and Tick-borne Diseases, 2017 ABSTRACT: Dermacentor reticulatus ticks are among the most important arthropod vectors of zoonotic disease agents in Europe. Eleven essential oils, namely basil (Ocimum basilicum), bergamot (Citrus bergamia), clove bud (Syzygium aromaticum), citronella (Cymbopogon winterianus), creeping thyme (Thymus serpyllum), lavender (Lavandula angustifolia), lemon-scented… Read more »

A systematic review of the effect of inhaled essential oils on sleep

Lillehei AS, Halcon LL Journal of Alternative and Complementary Medicine, 2014 ABSTRACT: OBJECTIVE: Sleep disturbances are recognized as an important health and public health problem that affects physical, mental, and emotional health and well-being. Inhalation of essential oils may be a safe alternative to pharmaceutical interventions for mild to moderate sleep disturbances. Quantitative human studies… Read more »