Terpinen-4-ol

  • Backbone: Monoterpene
  • Functional Group: Alcohol

Four terpene synthases contribute to the generation of chemotypes in tea tree (Melaleuca alternifolia)

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Padovan A, Keszei A, Hassan Y, Krause ST, Köllner TG, Degenhardt J, Gershenzon J, Külheim C, Foley WJ BMC Plant Biology, 2017 BACKGROUND: Terpene rich leaves are a characteristic of Myrtaceae. There is significant qualitative variation in the terpene profile of plants within a single species, which is observable as “chemotypes”. Understanding the molecular basis… Read more »

Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils

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Nikolić MM, Jovanović KK, Marković TL, Marković DL, Gligorijević NN, Radulović SS, Kostić M, Glamočlija JM, Soković MD Journal of Pharmacy and Pharmacology, 2017 OBJECTIVES: The chemical composition, antimicrobial and synergistic effect, and cytotoxic activity of Citrus limon (lemon), Piper nigrum (green pepper) and Melaleuca alternifoila (tea tree) essential oils (EOs) were investigated. METHODS: Chemical analyses of essential oils were tested… Read more »

Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species

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Nakayama K, Murata S, Ito H, Iwasaki K, Villareal MO, Zheng YW, Matsui H, Isoda H, Ohkohchi N Oncology Letters, 2017 ABSTRACT: Terpinen-4-ol (TP4O) is the main component of the essential oil extracted from Melaleuca alternifolia, known as the tea tree, of the botanical family Myrtaceae. The anticancer effects of TP4O have been reported in several cancer cell… Read more »

The Effects of Aromatherapy Massage on Sleep Quality of Nurses on Monthly Rotating Night Shifts

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Chang YY, Lin CL, Chang LY Evidence Based Complementary and Alternative Medicine, 2017 ABSTRACT: The goal of this study is to examine the effects of aromatherapy massage on sleep quality of nurses with monthly rotating night shifts. Subjects were enrolled at a medical center in central Taiwan with overall score ≥ 5 of Pittsburgh Sleep Quality Index… Read more »

A comparative study of antibacterial and anti-inflammatory effects of mouthrinse containing tea tree oil

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Salvatori C, Barchi L, Guzzo F, Gargari M ORAL & Implantology, 2017 ABSTRACT: The study evaluated the antibacterial and anti-inflammatory efficacy, domiciliary oral hygiene, of a mouthrinse containing Tea Tree Oil (TTO) comparing it with two mouthrinses containing chlorhexidine 0,12% respectively and essential oils, and a placebo. MATERIALS AND METHODS: A pilot study, randomized 4 × 4, controlled, cross-over,… Read more »

Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties

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Leyva-López N, Gutiérrez-Grijalva EP, Vazquez-Olivo G, Heredia JB Molecules, 2017 ABSTRACT: Essential oils of oregano are widely recognized for their antimicrobial activity, as well as their antiviral and antifungal properties. Nevertheless, recent investigations have demonstrated that these compounds are also potent antioxidant, anti-inflammatory, antidiabetic and cancer suppressor agents. These properties of oregano essential oils are of potential interest to the food,… Read more »

Studies on the Behavior of Eucalyptol and Terpinen-4-ol – Natural Food Additives and Ecological Pesticides – in Model Lipid Membranes

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Hąc-Wydro K, Flasiński M, Broniatowski M, Sołtys M Langmuir, 2017 ABSTRACT: Effective application of the essential oils requires detailed exploration of their mechanism of action and the origin of diverse activity of their components. In this work, the influence of eucalyptol and terpinen-4-ol on artificial membranes was studied to verify whether the differences in the activity of these compounds are… Read more »

Melaleuca (Melaleuca alternifolia) essential oil demonstrates tissue-remodeling and metabolism-modulating activities in human skin cells

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Han X, Parker TL Cogent Biology, 2017 ABSTRACT: Melaleuca (Melaleuca alternifolia) essential oil (MEO), commonly known as tea tree oil, is popularly used in skincare products. In the current study, we investigated the biological activity of a commercially available MEO (with terpinen-4-ol as the major active component) in pre-inflamed human dermal fibroblasts, which were designed… Read more »

Essential oils and their constituents as anticancer agents: a mechanistic view

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Gautam N, Mantha AK, Mittal S BioMed Research International, 2014 ABSTRACT: Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the… Read more »