Assaei R, Zal F, Mostafavi-Pour Z, Dabbaghmanesh MH, Geramizadeh B, Ranjbar Omrani GH, Pajouhi N
Iranian Journal of Medical Sciences, 2014
ABSTRACT:
BACKGROUND:
Hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. Thehepatoprotective effect of Satureja Khuzestanica Essential Oil (SKEO), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated.
METHODS:
Adult male sprague dawley rats were divided into categories of; control (group C), hyperthyroid (group H), hyperthyroid with oliveoil (group H+O), hyperthyroid with vitamin E (group H+E), hyperthyroid with SKEO (group H+S), combination of hyperthyroid with vitamin E and SKEO (group H+S+E). Hepatoprotective and antioxidant properties of SKEO with or without vitamin E in hyperthyroid rats were then investigated.
RESULTS:
Serum Aspartate Transaminase (AST) and Alanine Transaminase (ALT) activities reduced significantly in H+O, H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. Enzymes activities returned to normal in H+S+E group. Hepatic Malondialdehyde (MDA) was reduced in H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. The most significant MDA reduction was in the H+S+Egroup. Glutathione Peroxidase (GPx) and Glutathione Reductase (GR) activities increased in H+E, H+S and H+S+E groups in comparison with group H. The largest increment in GPx and GR activities were in the H+S+E group. Glutathione level did not change in any group in comparison with the control group.
CONCLUSION:
Administration of SKEO has hepatoprotective effect in hyperthyroid rats and is more effective when used in combination withvitamin E.
CITATION:
Assaei R, Zal F, Mostafavi-Pour Z, et al. Hepatoprotective Effect of Satureja Khuzestanica Essential Oil and Vitamin E in Experimental Hyperthyroid Rats: Evidence for Role of Antioxidant Effect. Iran J Med Sci. 2014;39(5):459-466.
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