Menezes PP, Araújo AA, Dória GA, Quintans-Júnior LJ, Oliveira MG, Santos MR, Oliveira JF, Matos JR, Carvalho FM, Alves PB, Matos IL, Santos DA, Marreto RN, Silva GF, Serafini MR
Current Pharmaceutical Biotechnology, 2014
ABSTRACT:
The formation of inclusion complexes of Hyptis pectinata essential oil (EOHP), with potent activities such as anti-nociceptive, anti-inflammatory, among others, with β-cyclodextrin (β-CD), was performed using slurry (SC) and paste procedures (PC). The gas chromatography coupled to the mass spectrometry (GC/MS) analysis showed a total volatile content of 36.4% monoterpenes and 63.6% sesquiterpenes in the EOHP. The major components of EOHP were identified as (E)-caryophyllene (54.07%). The characterization of the complex involved the analysis of EOHP, the surface and the total extracted oils. GC/MS results showed significant differences between the original oil, the SC and PC. Thermal characterization indicates the occurrence of complexation, mainly in SC, which presents a thermogravimetry/derivative thermogravimetry (TG/DTG) curve peak at 140-270 ºC, probably related to oil loss. Scanning electron microscopy (SEM) images showed decreased size of the samples especially in the SC product. Additionally, EOHP/ β-CD improves pharmacological profile of EOHP alone in formalin-induced pain protocol in mice.
CITATION:
Menezes PP, Araújo AA, Dória GA, et al. Physicochemical Characterization and Analgesic Effect of Inclusion Complexes of Essential Oil from Hyptis. Curr Pharm Biotechnol. 2014. [Epub ahead of print]
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