Oliveira-Tintino CDM, Pessoa RT, Fernandes MNM, Alcântara IS, da Silva BAF, de Oliveira MRC, Martins AOBPB, da Silva MDS, Tintino SR, Rodrigues FFG, da Costa JGM, de Lima SG, Kerntopf MR, da Silva TG, de Menezes IRA Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2018 ABSTRACT: BACKGROUND: Inflammation makes up a set of vascularized tissue… Read more »
Genomic Analysis of Terpene Synthase Family and Functional Characterization of Seven Sesquiterpene Synthases from Citrus sinensis
Alquézar B, Rodríguez A, de la Peña M, Peña L Frontiers in Plant Science, 2017 ABSTRACT: Citrus aroma and flavor, chief traits of fruit quality, are derived from their high content in essential oils of most plant tissues, including leaves, stems, flowers, and fruits. Accumulated in secretory cavities, most components of these oils are volatile terpenes. They… Read more »
Essential Oils of Hyptis pectinata Chemotypes: Isolation, Binary Mixtures and Acute Toxicity on Leaf-Cutting Ants
Feitosa-Alcantara RB, Bacci L, Blank AF, Alves PB, Silva IMA, Soares CA, Sampaio TS, Nogueira PCL, Arrigoni-Blank MF Molecules (Basel, Switzerland), 2017 ABSTRACT: Leaf-cutting ants are pests of great economic importance due to the damage they cause to agricultural and forest crops. The use of organosynthetic insecticides is the main form of control of these… Read more »
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice
Segat GC, Manjavachi MN, Matias DO, Passos GF, Freitas CS, Costa R, Calixto JB Neuropharmacology, 2017 ABSTRACT: Painful peripheral neuropathy is a common side effect of paclitaxel (PTX). The use of analgesics is an important component for management of PTX-induced peripheral neuropathy (PINP). However, currently employed analgesics have several side effects and are poorly effective. β-caryophyllene (BCP), a dietary selective CB2 agonist, has… Read more »
Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease Induced by MPTP
Viveros-Paredes JM, González-Castañeda RE, Gertsch J, Chaparro-Huerta V, López-Roa RI, Vázquez-Valls E, Beas-Zarate C, Camins-Espuny A, Flores-Soto ME Pharmaceuticals (Basel, Switzerland), 2017 ABSTRACT: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and is characterized by the loss of dopaminergic neurons in the substantia nigra (SN). Although the causes of PD are not understood, evidence suggests that its pathogenesis is associated… Read more »
β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway
Cheng Y, Dong Z, Liu S Pharmacology, 2014 ABSTRACT: BACKGROUND/AIMS: The activation of cannabinoid receptor 2 (CB2) has the beneficial effect of reducing neuroinflammatory response in the treatment of Alzheimer’s disease (AD) and is suggested to trigger the peroxisome proliferator-activated receptor-γ (PPARγ) pathway; agonists of both receptors improve AD. Recently, the plant metabolite β-caryophyllene was… Read more »