Han X, Rodriguez D, Parker TL Biochimie Open, 2017 ABSTRACT: Although frankincense essential oil (FREO) has become increasingly popular in skin care, research on its biological activities in human skin cells is scarce, if not completely absent. In the current study, we explored the biological activities of FREO in pre-inflamed human dermal fibroblasts by analyzing… Read more »
Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice
Lee SC, Wang SY, Li CC, Liu CT Journal of Food and Drug Analysis, 2018 ABSTRACT: Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demonstrated… Read more »
Anti-inflammatory Effect from a Hydrogel Containing Nanoemulsified Copaiba oil (Copaifera multijuga Hayne)
Lucca LG, de Matos SP, Kreutz T, Teixeira HF, Veiga VF Jr, de Araújo BV, Limberger RP, Koester LS AAPS PharmSciTech, 2017 ABSTRACT: Copaiba oil is used as a popular medicine in the Amazonian forest region, especially due to its anti-inflammatory properties. In this paper, we describe the formulation of hydrogel containing copaiba oil nanoemulsions (with positive and… Read more »
Trans-caryophyllene inhibits amyloid β (Aβ) oligomer-induced neuroinflammation in BV-2 microglial cells
Hu Y, Zeng Z, Wang B, Guo S International Immunopharmacology, 2017 ABSTRACT: Amyloid β (Aβ) is the major component of senile plaques (SP) in the brains of Alzheimer’s disease (AD) patients, and serves as an inflammatory stimulus for microglia. Trans-caryophyllene (TC), a major component in the essential oils derived from various species of medicinal plants, has displayed… Read more »
Effects of the essential oil of Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm. on healing and tissue repair after partial Achilles tenotomy in rats
Santos-Júnior L, Oliveira TVC, Cândido JF, Santana DS, Pereira RN Filho, Pereyra BBS, Gomes MZ, Lima SO, Albuquerque-Júnior RLC, Cândido Brazilian Surgical Acts, 2017 ABSTRACT: PURPOSE: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers. METHODS: Thirty wistar rats were divided in two groups after partial Achilles tenotomy: the right hind paw were… Read more »
Chemical composition analysis and in vitro biological activities of ten essential oils in human skin cells
Han X, Beaumont C, Stevens N, Parker TL Biochimie Open, 2017 ABSTRACT: Research on the biological effects of essential oils on human skin cells is scarce. In the current study, we primarily explored the biological activities of 10 essential oils (nine single and one blend) in a pre-inflamed human dermal fibroblast system that simulated chronic… Read more »
An essential oil blend significantly modulates immune responses and the cell cycle in human cell cultures
Han X, Dorsett J, Parker TL Cogent Biology, 2017 ABSTRACT: In the current study, we examined the biological activities of an essential oil blend (EOB) in validated human cell cultures, which model the molecular biology of autoimmune diseases and chronic inflammation. EOB is primarily composed of essential oils from wild orange, clove, cinnamon, eucalyptus, and… Read more »
Essential oils diversely modulate genome-wide gene expression in human dermal fibroblasts
Han X, Parker TL Cogent Medicine, 2017 ABSTRACT: The increasing popularity of essential oils for skincare has led to investigation of their biological effects in human skin cells. In this study, we investigated the biological activities of three commercially available essential oils, i.e. rosemary oil, wild orange oil, and a blend (commercial name: Deep Blue)… Read more »
An essential oil blend modulates important inflammation- and immune response-related biomarkers in human cell cocultures
Han X, Price R, Parker TL Cogent Medicine, 2017 ABSTRACT: Despite growing scientific evidence that essential oils possess important therapeutic benefits, research on their biological activities in complex human disease models is scarce. To enhance understanding in this regard, we analyzed the biological activities of an essential oil blend (EOB) in validated human cocultures with… Read more »
Biological activity of vetiver (Vetiveria zizanioides) essential oil in human dermal fibroblasts
Han X, Parker TL Cogent Medicine, 2017 ABSTRACT: Vetiver (Vetiveria zizanioides) essential oil (VEO) has a long history of use. However, research on its biological activity in human skin cells is scarce. In this study, we investigated the biological activity of VEO in a pre-inflamed human dermal fibroblast model, which was designed to mimic the… Read more »