Ohara K, Katayama M, Nagai K Neuroscience Letters, 2018 ABSTRACT: The autonomic nervous system innervates various peripheral tissue functions. Various external stimuli affect autonomic nerve activity, however, there is little information about the involvement of sensory receptors in the responses. The TRPA1 is a calcium-permeable non-selective cation channel which plays a crucial role in the… Read more »
Antiparasitic activity of nerolidol in a mouse model of schistosomiasis
Silva MP, de Oliveira RN, Mengarda AC, Roquini DB, Alegretti SM, Salvadori MC, Teixeira FS, de Sousa DP, Pinto PLS, de Moraes J International Journal of Antimicrobial Agents, 2017 ABSTRACT: Schistosomiasis is a major public health problem worldwide, especially in poor communities. Since praziquantel is currently the only drug available to treat schistosomiasis, there is an urgent need to identify new antischistosomal drugs. Nerolidol… Read more »
Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships
Vasconcelos CML, Oliveira ISN, Santos JNA, Souza AA, Menezes-Filho JER, Silva Neto JA, Lima TC, de Sousa DP Natural Product Research, 2017 ABSTRACT: The aim of this work was to evaluate the pharmacological effect of seven structurally related terpenes on the contractility of cardiac muscle. The effect of terpenes was studied on isolated electrically driven guinea pig left atrium. From concentration-response curves… Read more »
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures
de Oliveira CC, de Oliveira CV, Grigoletto J, Ribeiro LR, Funck VR, Grauncke AC, de Souza TL, Souto NS, Furian AF, Menezes IR, Oliveira MS Epilepsy & behavior : E&B, 2016 ABSTRACT: Increasing evidence suggests that plant-derived extracts and their isolated components are useful for treatment of seizures and, hence, constitute a valuable source of… Read more »