Relaxant effect of Lippia origanoides essential oil in guinea-pig trachea smooth muscle involves potassium channels and soluble guanylyl cyclase

Menezes PMN, Brito MC, Paiva GO, Santos COD, Oliveira LM, Ribeiro LAA, Lima JT, Lucchese AM, Silva FS Journal of Ethnopharmacology, 2018 ABSTRACT: ETHNOPHARMACOLOGICAL RELEVANCE: Lippia origanoides H.B.K. is an aromatic species used in folk medicine to treat respiratory diseases, including asthma. AIM OF THE STUDY: The aim of this work was to evaluate the… Read more »

Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol

do Nascimento KF, Moreira FMF, Alencar Santos J, Kassuya CAL, Croda JHR, Cardoso CAL, Vieira MDC, Góis Ruiz ALT, Ann Foglio M, de Carvalho JE, Formagio ASN Journal of Ethnopharmacology, 2017 ETHNOPHARMACOLOGICAL RELEVANCE: Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence… Read more »

Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone

Detremmerie C, Vanhoutte PM, Leung S Acta Pharmaceutica Sinica. B, 2017 ABSTRACT: The natural compound thymoquinone, extracted from Nigella sativa (black cumin), is widely used in humans for its anti-oxidative properties. Thymoquinone is known for its acute endothelium-independent vasodilator effects in isolated rat aortae and pulmonary arteries, depending in part on activation of adenosine triphosphate-sensitive potassium channels and inhibition… Read more »

Chemical Composition and Antimigraine Activity of Essential Oil of Angelicae dahuricae Radix

Sun J, Li H, Sun J, Liu H, Chen J, Wang C Journal of Medicinal Food, 2017 ABSTRACT: The aim of this study was to explore the chemical composition and the effect of essential oil of Angelicae dahuricae radix on a nitroglycerin (NTG)-induced rat model of migraine. The CO2 supercritical fluid extraction method was optimized for the extraction of essential oil of A. dahuricae radix… Read more »