Hepatotoxicity of monoterpenes and sesquiterpenes

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Zárybnický T, Boušová I, Ambrož M, Skálová L Archives of Toxicology, 2017 ABSTRACT: Public interest in natural therapies has increased significantly over past decades. Herbs and herbal products are extensively consumed worldwide and they are generally considered as safe. However, this may not always be true as many cases of herb-induced liver injury are reported… Read more »

Effect of eugenol on lithium-pilocarpine model of epilepsy: behavioral, histological, and molecular changes

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Joushi S, Salmani ME Iranian Journal of Basic Medical Sciences, 2017 OBJECTIVES: Epilepsy establishment gives rise to biochemical and morphological changes in the hippocampus. Oxidative stress, morphological changes, and mossy fiber sprouting (MFS) in the hippocampus underpin the epilepsy establishment. Eugenol is the main component of the essential oil extracted from cloves with the potential to modulate… Read more »

Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats

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Ozkaya A, Sahin Z, Kuzu M, Saglam YS, Ozkaraca M, Uckun M, Yologlu E, Comakli V, Demirdag R, Yologlu S Archives of Physiology and Biochemistry, 2017 ABSTRACT: In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated…. Read more »

Anethole Inhibits The Proliferation Of Human Prostate Cancer Cells Via Induction Of Cell Cycle Arrest And Apoptosis

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Elkady AI Anti-Cancer Agents in Medicinal Chemistry, 2017 ABSTRACT: BACKGROUND: Prostate cancer-associated mortality is increasing at an alarming rate, which highlights the inevitability for unearthing novel agent for the management of this disease. Anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, is widely used in folk medicine; it possesses anti-oxidant, anti-inflammatory, anti-proliferative and tumoricidal potentialities…. Read more »

Potential protective effects of alpha-pinene against cytotoxicity caused by aspirin in the IEC-6 cells

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Bouzenna H, Hfaiedh N, Giroux-Metges MA, Elfeki A, Talarmin H Biomedicine & Pharmacotherapy, 2017 ABSTRACT: Alpha-pinene is a key compound of the essential oils extracted from many species of coniferous trees. It is known for its biological activities. The aim of the present study was to determine the preventive effect of alpha-pinene on aspirin-induced toxicity in vitro, using IEC-6 cells, and… Read more »

Thymol reduces oxidative stress, aortic intimal thickening, and inflammation-related gene expression in hyperlipidemic rabbits

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Yua YM, Chaob TY, Changb WC, Changb MJ, Leea MF Journal of Food and Drug Analysis, 2016 ABSTRACT: Atherosclerosis plays a key role in the development of cardiovascular diseases, and is often associated with oxidative stress and local inflammation. Thymol, a major polyphenolic compound in thyme, exhibits antioxidant and anti-inflammatory properties. In this study, we… Read more »

Zingiberene attenuates hydrogen peroxide-induced toxicity in neuronal cells

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Togar B, Türkez H, Stefano AD, Tatar A, Cetin D Human & experimental toxicology, 2015 ABSTRACT: In this experimental design, we explored the neuroprotective potential of zingiberene (ZGB), a monocyclic sesquiterpene, in hydrogen peroxide (H2O2)-induced toxicity in newborn rat cerebral cortex cell cultures for the first time. The rats were exposed to H2O2 for 6… Read more »